The transcriptional regulators TAZ and YAP (TAZ/YAP) have emerged as pro-tumorigenic factors that drive many oncogenic traits, including induction of cell growth, resistance to cell death, and activation of processes that promote migration and invasion. Here, we report that TAZ/YAP reprogram cellular energetics to promote the dependence of breast cancer cell […]
Yang, C.-S., Stampouloglou, E., Kingston, N. M., Zhang, L., Monti, S., Varelas, X.
Mitochondria are double-membrane-bound organelles that constantly change shape through membrane fusion and fission. Outer mitochondrial membrane fusion is controlled by Mitofusin, whose molecular architecture consists of an N-terminal GTPase domain, a first heptad repeat domain (HR1), two transmembrane domains, and a second heptad repeat domain (HR2). The mo […]
Daste, F., Sauvanet, C., Bavdek, A., Baye, J., Pierre, F., Le Borgne, R., David, C., Rojo, M., Fuchs, P., Tareste, D.
Th17 cells contribute to the development of autoimmune diseases by secreting interleukin-17 (IL-17), which activates its receptor (IL-17R) that is expressed on epithelial cells, macrophages, microglia, and resident neuroectodermal cells. However, the mechanisms through which IL-17R-mediated signaling contributes to the development of autoimmune disease have […]
Lin, W., Wang, N., Zhou, K., Su, F., Jiang, Y., Shou, J., Liu, H., Ma, C., Qian, Y., Wang, K., Wang, X.
The production of type I interferon (IFN) is essential for cellular barrier functions and innate and adaptive antiviral immunity. In response to virus infections, RNA receptors RIG-I and MDA5 stimulate a mitochondria-localized signaling apparatus that uses TRAF family ubiquitin ligase proteins to activate master transcription regulators IRF3 and NFB, driving […]
Parisien, J.-P., Lenoir, J. J., Mandhana, R., Rodriguez, K. R., Qian, K., Bruns, A. M., Horvath, C. M.
Yes-associated protein (YAP) is a transcriptional co-activator and a major effector of the Hippo pathway that promotes cell proliferation and stemness, while inhibiting apoptosis. YAP plays a central role in organ size control, and its deregulation strongly promotes cancer initiation and progression. However, the mechanisms by which YAP promotes cell invasio […]
Cellular senescence is a unique cell fate characterized by stable proliferative arrest and the extensive production and secretion of various inflammatory proteins, a phenomenon known as the senescence-associated secretory phenotype (SASP). The molecular mechanisms responsible for generating a SASP in response to senescent stimuli remain largely obscure. Here […]
Chong, M., Yin, T., Chen, R., Xiang, H., Yuan, L., Ding, Y., Pan, C. C., Tang, Z., Alexander, P. B., Li, Q.-J., Wang, X.-F.
Alternative pre-mRNA splicing plays important roles in regulating self-renewal and differentiation of embryonic stem cells (ESCs). However, how specific alternative splicing programs are established in ESCs remains elusive. Here, we show that a subset of alternative splicing events in ESCs is dependent on miR-294 expression. Remarkably, roughly 60% of these […]
A team of students and staff from the University of Exeter are set to embark on a 12-day voyage to measure pollution in the Arctic Their aim: to make the unseen seen. By collecting vital baseline data on the non-visible pollutants lurking beneath the sea’s surface and with a diverse crew of film-makers, artists, photographers, […]
To celebrate the launch of the inaugural Wildscreen Photo Story Panda Award at this year’s Wildscreen Festival, Arkive is getting to know the award’s amazing team and jury, who are themselves international photography professionals. Here we meet Neil Aldridge. Neil Aldridge is the Technical Consultant for the Wildscreen Photo Story Panda Award. As a conserva […]
Wildscreen is partnering with the International League of Conservation Photographers at Wildscreen Festival 2018 where many of it’s fellows and associates will be speaking at the festival this October. We spoke with Susan Norton, iLCP’s Executive Director, about the organisation and their role supporting conservation photographers. Tell us a little more abou […]
To celebrate the launch of the inaugural Wildscreen Photo Story Panda Award at this year’s Wildscreen Festival, Arkive is getting to know the award’s amazing jury, who are themselves international photography professionals. Here we meet Britta Jaschinski. For over 20 years, Britta Jaschinski has been devoted to documenting the fractured existence of wildlife […]