Members of an isolated Amazon tribe in Venezuela (pictured) have the most diverse gut bacteria ever documented in humans.Maria Gloria Dominguez-Bello at New York University School of Medicine analysed oral, faecal and skin bacteria from 34 Yanomami villagers who had never met anyone from
The sweet-potato genome contains genes from bacteria, so is an example of a naturally occurring genetically modified (GM) plant.While combing through the genome of the domesticated sweet potato (Ipomoea batatas), Jan Kreuze of the International Potato Center in Lima, Peru, and his
The 1815 eruption of Tambora caused an unusually cold summer in much of Europe in 1816. The extreme weather led to poor harvests and malnutrition, but also demonstrated the capability of humans to adapt and help others in worse conditions.
200 years after the eruption of Mount Tambora, the eruption volume remains poorly known, as is true for other volcanic eruptions over past millennia. We need better records of size and occurrence if we are to predict future large eruptions more accurately.
The innate immune system detects microbes and abnormal self through pattern recognition receptors (PRRs), which detect molecules that are either specific for microbes (such as lipopolysaccharide), present in much higher concentrations during infection (such as double-stranded RNA), or present in aberrant locations (such as cytosolic DNA) . The Toll-like r […]
Inflammation entails a complex set of defense mechanisms acting in concert to restore the homeostatic balance in organisms after damage or pathogen invasion. This immune response consists of the activity of various immune cells in a highly complex manner. Inflammation is a double-edged sword as it is reported to have both detrimental and beneficial consequen […]
IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, n […]
Toll-like receptors (TLRs) are pattern recognition receptors that sense a variety of pathogens, initiate innate immune responses, and direct adaptive immunity. All TLRs except TLR3 recruit the adaptor MyD88 to ultimately elicit inflammatory gene expression, whereas TLR3 and internalized TLR4 use TIR-domain-containing adaptor TRIF for the induction of type I […]
FOXO transcription factors are considered bona fide tumor suppressors; however, recent studies showed FOXOs are also required for tumor survival. Here, we identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. In cancer cells carrying mutant IDH1, FOXOs likew […]
Charitou, P., Rodriguez-Colman, M., Gerrits, J., van Triest, M., Groot Koerkamp, M., Hornsveld, M., Holstege, F., Verhoeven-Duif, N. M., Burgering, B. M.
Reductions in brain glucose metabolism have long been associated with Alzheimer's disease. A study now demonstrates that the endothelial glucose transporter GLUT1 is vital for maintaining brain energy metabolism and vascular clearance of amyloid-β.
Chronic cocaine exposure induces long-lasting, transcription-dependent changes in neuronal function. A genome-wide sequencing study shows how cocaine changes the epigenome to exert specific, long-lasting effects on neuronal transcription.
Head direction cells have been hypothesized to form representations of an animal's spatial orientation through internal network interactions. New data from mice show the predicted signatures of these internal dynamics.
Arkive’s Week in Review — Wildlife News ICYMI: Arkive has compiled some of the biggest and most interesting headlines from this week. Article originally published on Friday, Apr 17, 2015 Your name here: auctioning the naming rights to new species to fund conservation Ecologist, Mary Lowman was on a mission to save Ethiopia’s church forests […]
Happy Earth Day Everyone! The theme for Earth Day this year is, “It’s Our Turn To Lead”. Our friends at Earth Day Network are urging people to learn more about the topic of climate change which generally refers to man-made changes to the environment that have contributed to the steady rise in the earth’s temperature, rising […]
Arkive’s Week in Review — Wildlife News ICYMI: Arkive has compiled some of the biggest and most interesting headlines from this week. Article originally published on Friday, Apr 10, 2015 Elephant mother and calf reunite after 3 years apart MeBai, a female Asian elephant, was just three years old when she was separated from her […]
Arkive’s Week in Review — Wildlife News ICYMI: Arkive has compiled some of the biggest and most interesting headlines from this week. Article originally published on Friday, Apr 3, 2015 ‘Lazy’ sea lion sons rely on mothers milk while diligent daughters learn to hunt For the first two years of their life, male Galapagos sea […]