Authors of research manuscripts should be aware of their authorship, have read the paper and agree with it. What else is required for co-authorship — and what merits only a mention in the acknowledgements — is less clear.
Glaciers and ice sheets are retreating in response to climate warming. An analysis of drainage patterns of a huge glacier in Yukon, Canada shows that glacier retreat has led to a drastic change in the destination of its meltwater in spring 2016.
Transcription is tightly regulated in response to DNA damage. Rapid and transient pausing of RNA polymerase II (RNAPII) is indeed critical to restrict the production of aberrant transcripts from damaged loci and to prevent deleterious collisions between transcription and repair machineries. Yet, how DNA lesions signal to the transcription machinery to coordi […]
Membrane receptors and ion channels respond to various stimuli and relay that information across the plasma membrane by triggering specific and timed processes. These include activation of second messengers, allowing ion permeation, and changing cellular excitability, to name a few. Gaining control over equivalent processes is essential to understand neurona […]
Efficient neuronal function depends on the continued modulation of the local neuronal proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at specific neuronal regions. Various aspects of translation such as the localization of translational machinery, spatial spread of the newly translated proteins, and their site of action […]
Wnt/β-catenin signaling plays a key role in embryonic development, stem cell biology, and neurogenesis. However, the mechanisms of Wnt signal transmission, notably how the receptors are regulated, remain incompletely understood. Here we describe that the Parkinson's disease-associated receptor GPR37 functions in the maturation of the N-terminal bulky β- […]
Berger, B. S., Acebron, S. P., Herbst, J., Koch, S., Niehrs, C.
Type IV secretion systems (T4SSs) are large macromolecular machines that translocate protein and DNA and are involved in the pathogenesis of multiple human diseases. Here, using electron cryotomography (ECT), we report the in situ structure of the Dot/Icm type IVB secretion system (T4BSS) utilized by the human pathogen Legionella pneumophila. This is the fir […]
Ghosal, D., Chang, Y.-W., Jeong, K. C., Vogel, J. P., Jensen, G. J.
α-Synuclein is present at high levels in all neurons and their synapses. We now learn that this protein helps dilate the fusion pore, which forms transiently during vesicle exocytosis, promoting release of certain neurotransmitters.
Capillary endothelial cells sense neuronal activity-evoked increases in extracellular K+ via KIR2.1 inwardly rectifying K+ channels. The ensuing hyperpolarization travels upstream along the vascular network, reaching arterioles and evoking vasodilation.
Technical advances in calcium imaging enable the first tests of classic theories of cerebellar learning. Two independent groups reveal dense representation of surprising modalities in cerebellar granule cells.
A study combines monkey behavioral testing with electrical stimulation of face patches, located with functional MRI and studied electrophysiologically, to probe the behavioral relevance of the face patches' selectivity.
As it’s Arkive’s 14th birthday, we thought we would celebrate by sharing 14 ways that you can help save the world! By just doing one of these things you can make a difference, more than one you can make a big difference, and by doing all 14 you are very much on track to save […]
Daniel Craven is Durrell Wildlife Conservation Trust‘s Volunteer Manager, based at Jersey Zoo since 2001. A former professional footballer, Daniel is a lover of travel, animals and conservation. Durrell’s Underdogs is his first film and was made with the fantastic team of Dean Maryon, Bex Bohea, Shaz Syed and Marc Mitchell. It is an official […]
Arkive would like to introduce The Wait, a short film from production company Contra, which follows the journey of a wildlife photographer on a hunt to document the elusive European bison in its natural habitat of the Romanian mountains. The story details how it can take weeks to capture a shot, and the patience required to […]
In this guest blog, wildlife photographer and Wildscreen Exchange contributor Avijan Saha discusses his experience with human-animal conflict in West Bengal, India, where an ancient Asian elephant migratory route has been blocked by a 20-kilometre-long fence, and the implications it has caused for both wildlife and human communities. My name is Avijan Saha, […]