A catastrophic 2013 flood in China was probably caused, in part, by air pollution.In July 2013, heavy rainfall resulted in a devastating flood in the mountains northwest of the Sichuan Basin in China (pictured). The basin has seen increasing industrial activity in the past
By counting the number of endangered panthers hit and killed by cars in Florida, researchers have estimated the population size of this rare cat. They say that it is the first statistically robust population estimate for the animals across their breeding range.Brett McClintock of
The history of attempts to spread scientific know-how beyond western centres of excellence is littered with failures. Capacity building needs long-term commitment, a critical mass of trainees, and a supportive home environment.
Earth's crust was thought to deform uniformly over most of the seismic cycle. Analysis of two centuries of nautical surveys from Chile reveals temporal variability that complicates our view of time-dependent seismic hazards.
Embryonic stem cell (ESC) cultures display a heterogeneous gene expression profile, ranging from a pristine naïve pluripotent state to a primed epiblast state. Addition of inhibitors of GSK3β and MEK (so-called 2i conditions) pushes ESC cultures toward a more homogeneous naïve pluripotent state, but the molecular underpinnings of this naïve transition are no […]
Welling, M., Chen, H.-H., Munoz, J., Musheev, M. U., Kester, L., Junker, J. P., Mischerikow, N., Arbab, M., Kuijk, E., Silberstein, L., Kharchenko, P. V., Geens, M., Niehrs, C., van de Velde, H., van Oudenaarden, A., Heck, A. J., Geijsen, N.
Epigenetic modifications, such as DNA methylation and histone modifications, are dynamically altered predominantly in paternal pronuclei soon after fertilization. To identify which histone modifications are required for early embryonic development, we utilized histone K-M mutants, which prevent endogenous histone methylation at the mutated site. We prepared […]
Ups1 forms a complex with Mdm35 and is critical for the transport of phosphatidic acid (PA) from the mitochondrial outer membrane to the inner membrane. We report the crystal structure of the Ups1-Mdm35-PA complex and the functional characterization of Ups1-Mdm35 in PA binding and transfer. Ups1 features a barrel-like structure consisting of an antiparallel […]
The composition of the mitochondrial membrane is important for its architecture and proper function. Mitochondria depend on a tightly regulated supply of phospholipid via intra-mitochondrial synthesis and by direct import from the endoplasmic reticulum. The Ups1/PRELI-like family together with its mitochondrial chaperones (TRIAP1/Mdm35) represent a unique he […]
Miliara, X., Garnett, J. A., Tatsuta, T., Abid Ali, F., Baldie, H., Perez-Dorado, I., Simpson, P., Yague, E., Langer, T., Matthews, S.
Epidemiological studies and anecdotal evidence show overlap between psychiatric disorders and creativity, but why? A new study uses genome-wide association data from schizophrenia and bipolar disorder to show that genetics are part of the explanation.
Discovering the environmental factors that control microglia is key to understanding and managing brain health. A new study finds that microbiota in the gut are essential to the regulation of microglial maturation and activation.
Schizophrenia-linked single nucleotide polymorphisms in MIR137 alter expression of miR-137 in neurons. Abnormal expression of miR-137 affects vesicle release at presynaptic terminals and in turn alters hippocampal functioning.
Arkive’s Week in Review — Wildlife News ICYMI: Arkive has compiled some of the biggest and most interesting headlines from this week. Article originally published on Friday, Jun 26, 2015 More endangered pygmy sloths discovered in Panama than previously estimated Researchers estimate that there are between 500 – 1500 pygmy sloths residing on the Isla […] […]
Arkive’s Week in Review — Wildlife News ICYMI: Arkive has compiled some of the biggest and most interesting headlines from this week. Article originally published on Friday, Jun 19, 2015 Hawk-moths are capable of slowing their brains to stay in rhythm with their environment Hawk moths can slow parts of their brain in order to […]
Arkive’s Week in Review — Wildlife News ICYMI: Arkive has compiled some of the biggest and most interesting headlines from this week. Article originally published on Friday, Jun 12, 2015 U.S. grants new protections for captive chimpanzees On June 12th the US Fish and Wildlife Service declared that all chimpanzees both in the wild and […]
Do you love camels as much we do? The Arkive Team had the wonderful opportunity to chat with the amazing folks at the Wild Camel Protection Foundation to learn all about what they do and their current essay competition with cash prizes! Can camels drink saltwater? Did you know that you can help camel conservation right […]