A brain implant that is wired to a robotic arm has allowed a paralysed man to feel touch on the arm's fingers.Robert Gaunt at the University of Pittsburgh in Pennsylvania and his colleagues placed electrodes in the brain of Nathan Copeland (pictured), whose legs
Young stars are surrounded by a rotating disk of gas and dust, from which planets are born — but astronomers have discovered that one pair of young stars orbiting around each other has three disks, not just two.Christian Brinch at the University of Copenhagen
A small molecule produced by bacteria living naturally in people can help to combat a pathogen that is resistant to many antibiotics.Sean Brady at the Rockefeller University in New York City and his colleagues analysed the genomes of the human microbiota to identify genes
The composition of Earth's crust depends on the style of plate tectonics and of the melting regimes in the mantle. Analyses of the oldest identified rocks suggest that these styles and the resulting crust have changed over Earth's history.
Increasing groundwater extraction supports hundreds of millions of people across the Indo-Gangetic Basin. Data suggests that despite the increase in withdrawals, groundwater depletion is localized and the most widespread threat is contamination.
There is potential evidence for a stratified layer at the top of the Earth's core, but its origin is not well understood. Laboratory experiments suggest that the stratified layer could be a sunken remnant of the giant impact that formed the Moon.
In convergent evolution, similar environmental conditions produce similar sets of adaptations. Does similar convergence exist in the molecular underpinnings of such morphological changes? – [Read More]
Pain experienced by an individual can be modulated by social, cognitive, and emotional factors. In a group setting, can an individual experiencing pain affect other, pain-free individuals' – [Read More]
Mechanisms of CO2/H+ Sensitivity of Astrocytes Turovsky, E., Theparambil, S. M., Kasymov, V., Deitmer, J. W., del Arroyo, A. G., Ackland, G. L., Corneveaux, J. J., Allen, A. N., Huentelman, M. J., Kasparov, S., Marina, N., Gourine, A. V.
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by one of four members of the eIF2α kinase family, which leads to a decrease […]
Pakos-Zebrucka, K., Koryga, I., Mnich, K., Ljujic, M., Samali, A., Gorman, A. M.
Correct orientation of cell division is considered an important factor for the achievement of normal brain size, as mutations in genes that affect this process are among the leading causes of microcephaly. Abnormal spindle orientation is associated with reduction of the neuronal progenitor symmetric divisions, premature cell cycle exit, and reduced neurogene […]
Gai, M., Bianchi, F. T., Vagnoni, C., Verni, F., Bonaccorsi, S., Pasquero, S., Berto, G. E., Sgro, F., Chiotto, A. M., Annaratone, L., Sapino, A., Bergo, A., Landsberger, N., Bond, J., Huttner, W. B., Di Cunto, F.
Hypoxia-inducible factor (HIF) directs an extensive transcriptional cascade that transduces numerous adaptive responses to hypoxia. Pan-genomic analyses, using chromatin immunoprecipitation and transcript profiling, have revealed large numbers of HIF-binding sites that are generally associated with hypoxia-inducible transcripts, even over long chromosomal di […]
Platt, J. L., Salama, R., Smythies, J., Choudhry, H., Davies, J. O., Hughes, J. R., Ratcliffe, P. J., Mole, D. R.
Iodine antiseptics exhibit superior antimicrobial efficacy and do not cause acquired microbial resistance. However, they are underused in comparison with antibiotics in infection treatments, partly because of their adverse effects such as pain and allergy. The cause of these noxious effects is not fully understood, and no specific molecular targets or mechan […]
Su, D., Zhao, H., Hu, J., Tang, D., Cui, J., Zhou, M., Yang, J., Wang, S.
Congenital stationary night blindness (CSNB) is an inherited and non-progressive retinal dysfunction. Here, we present the crystal structure of CSNB-causing T94I2.61 rhodopsin in the active conformation at 2.3 Å resolution. The introduced hydrophobic side chain prolongs the lifetime of the G protein activating metarhodopsin-II state by establishing a direct […]
Singhal, A., Guo, Y., Matkovic, M., Schertler, G., Deupi, X., Yan, E. C., Standfuss, J.
The 7SK snRNA sequesters P-TEFb, a general transcription elongation factor and human co-factor for HIV-1 Tat protein, into the catalytically inactive 7SK snRNP. Little is known about how 7SK RNA is regulated to perform this function. Here, we show that most of 7SK is pseudouridylated at position U250 by the predominant cellular pseudouridine synthase machine […]
Neurons require lifelong maintenance of their transcriptional program, which includes stable expression of cell-type-specific identity genes. A study now shows that PRC2-mediated chromatin repression in adulthood is critical for the maintenance of neuronal identity gene expression and neuronal survival.
Sound information travels from auditory cortex to lateral amygdala, but a newly identified pathway runs in the opposite direction. It undergoes plasticity and is required for memory recall during auditory fear conditioning.
While the relationship between motivation and sleep is intuitive, its behavioral and neural features are poorly understood. A new study tackles both issues, showing that dopaminergic neurons in the ventral tegmental area mediate this relationship.
Wildscreen recently worked with world-renowned street artist Louis Masai to create two beautiful murals in our hometown of Bristol, UK to mark the beginning of the Wildscreen Festival and raise awareness of two little-known endangered species. This painting event was part of Wildscreen’s Witness the Wild programme, a series of free-to-attend events from 21/0 […]
Vanishing Kings – Lions of the Namib is a film created by Will and Lianne Steenkamp that has been nominated for a 2016 Panda Award for Cinematography (Small Crew). We were still on a high from the amount of hard work that the public and conservation organisations had put into raising awareness of World Lion Day on 10 […]
August 10th is World Lion Day so we’ve collated a list of some of our favourite lion facts to celebrate – and we are all planning on watching the Lion King when we get home too! 1) Lions and the British Monarchy Lions have long been a symbol of of the British Monarchy; some of the earliest […]
August 8th is International Cat Day, but before you open up the catnip for your domestic moggy why not take a look at their wild relatives? There are 41 cat species in the Felidae family and while the more famous members steal most of the limelight, there are probably quite a few species that you haven’t even […]