Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs abortive topoisomerase II cleavage complexes. Here, we identify a novel short isoform of TDP2 (TDP2S) expressed from an alternative transcription start site. TDP2S contains a mitochondrial targeting sequence, contributing to its enrichment in the mitochondria and cytosol, while full-length TDP2 contains a nuclea […]
Huang, S.-y. N., Dalla Rosa, I., Michaels, S. A., Tulumello, D. V., Agama, K., Khiati, S., Jean, S. R., Baechler, S. A., Factor, V. M., Varma, S., Murai, J., Miller Jenkins, L. M., Kelley, S. O., Pommier, Y.
Unlike other neural peripheral organs, the adult carotid body (CB) has a remarkable structural plasticity, as it grows during acclimatization to hypoxia. The CB contains neural stem cells that can differentiate into oxygen-sensitive glomus cells. However, an extended view is that, unlike other catecholaminergic cells of the same lineage (sympathetic neurons […]
Sobrino, V., Gonzalez-Rodriguez, P., Annese, V., Lopez-Barneo, J., Pardal, R.
AKT signaling is modulated by a complex network of regulatory proteins and is commonly deregulated in cancer. Here, we present a dual mechanism of AKT regulation by the ERBB receptor feedback inhibitor 1 (ERRFI1). We show that in cells expressing high levels of EGFR, ERRF1 inhibits growth and enhances responses to chemotherapy. This is mediated in part throu […]
Cairns, J., Fridley, B. L., Jenkins, G. D., Zhuang, Y., Yu, J., Wang, L.
Aberrant centrosome organisation with ensuing alterations of microtubule nucleation capacity enables tumour cells to proliferate and invade despite increased genomic instability. CEP192 is a key factor in the initiation process of centrosome duplication and in the control of centrosome microtubule nucleation. However, regulatory means of CEP192 have remained […]
Fung, E., Richter, C., Yang, H.-B., Schäffer, I., Fischer, R., Kessler, B. M., Bassermann, F., D'Angiolella, V.
MicroRNAs are important regulators of local protein synthesis during neuronal development. We investigated the dynamic regulation of microRNA production and found that the majority of the microRNA-generating complex, consisting of Dicer, TRBP, and PACT, specifically associates with intracellular membranes in developing neurons. Stimulation with brain-derived […]
Antoniou, A., Khudayberdiev, S., Idziak, A., Bicker, S., Jacob, R., Schratt, G.
Mitochondrial dysfunction in the nigrostriatal dopaminergic system is a critical hallmark of Parkinson's disease (PD). Mitochondrial toxins produce cellular and behavioural dysfunctions resembling those in patients with PD. Causative gene products for familial PD play important roles in mitochondrial function. Therefore, targeting proteins that regulate […]
Inoue, N., Ogura, S., Kasai, A., Nakazawa, T., Ikeda, K., Higashi, S., Isotani, A., Baba, K., Mochizuki, H., Fujimura, H., Ago, Y., Hayata-Takano, A., Seiriki, K., Shintani, Y., Shintani, N., Hashimoto, H.
Target of rapamycin (TOR) kinase controls cell growth and metabolism in response to nutrient availability. In the fission yeast Schizosaccharomyces pombe, TOR complex 1 (TORC1) promotes vegetative growth and inhibits sexual differentiation in the presence of ample nutrients. Here, we report the isolation and characterization of mutants with similar phenotype […]
Otsubo, Y., Matsuo, T., Nishimura, A., Yamamoto, M., Yamashita, A.
Despite progress in treating B-cell precursor acute lymphoblastic leukemia (BCP-ALL), disease recurrence remains the main cause of treatment failure. New strategies to improve therapeutic outcomes are needed, particularly in high-risk relapsed patients. Che-1/AATF (Che-1) is an RNA polymerase II-binding protein involved in proliferation and tumor survival, b […]
Folgiero, V., Sorino, C., Pallocca, M., De Nicola, F., Goeman, F., Bertaina, V., Strocchio, L., Romania, P., Pitisci, A., Iezzi, S., Catena, V., Bruno, T., Strimpakos, G., Passananti, C., Mattei, E., Blandino, G., Locatelli, F., Fanciulli, M.
PIWI-interacting RNAs (piRNAs) are germ cell-specific small RNAs essential for retrotransposon gene silencing and male germ cell development. In piRNA biogenesis, the endonuclease MitoPLD/Zucchini cleaves long, single-stranded RNAs to generate 5' termini of precursor piRNAs (pre-piRNAs) that are consecutively loaded into PIWI-family proteins. Subsequent […]
Nishimura, T., Nagamori, I., Nakatani, T., Izumi, N., Tomari, Y., Kuramochi-Miyagawa, S., Nakano, T.
The race to become crowned as the World’s Most Unloved Species was hotly contested, once again, this year with 19 nominated species in the running. After 12 days of fierce competition, impassioned pitches and over 4,500 votes, the top 10 was announced on Valentine’s Day. But slithering into first place… it’s the Galapagos racer! Often […]
Species name: thorny skate Nominated by: Shark Advocates International IUCN Red List classification: Vulnerable What is so special about your species? Thorny skates have amazing features, support substantial fisheries, and face serious threats. Yet, they get so little love. This fierce-looking, bottom-dwelling species has a dozen or more large thorns running […]
Species name: goliath frog Nominated by: Synchronicity Earth IUCN Red List classification: Endangered What is so special about your species? The goliath frog is the world’s largest frog. It is known only from south-western Cameroon from the region of Nkongsamba, and south to Monte Alen in mainland Equatorial Guinea. It is generally found at low to […]
Species name: shortfin mako Nominated by: The Shark Trust IUCN Red List classification: Vulnerable; Critically Endangered – Mediterranean What is so special about your species? Sleek and fast, the shortfin mako is capable of reaching speeds of over 30mph, making it the fastest shark in the world. On top of this, it has the power to […]