The bacterial type VI secretion system (T6SS) is a multicomponent complex responsible for the translocation of effector proteins into the external milieu. The T6SS consists of an external sheath, an internal rigid tube, a baseplate, and a T6SS-specific membrane complex. Secretion is accomplished by the contraction of the sheath, which expels the effector-loa […]
Zika and dengue viruses belong to the Flavivirus genus, a close group of antigenically related viruses that cause significant arthropod-transmitted diseases throughout the globe. Although infection by a given flavivirus is thought to confer lifelong protection, some of the patient's antibodies cross-react with other flaviviruses without cross-neutralizi […]
Rey, F. A., Stiasny, K., Vaney, M.-C., Dellarole, M., Heinz, F. X.
Secretion systems are essential for bacteria to survive and manipulate their environment. The bacterial type VI secretion system (T6SS) generates the force needed for protein translocation by the contraction of a long polymer called sheath. The sheath is a six-start helical assembly of interconnected VipA/VipB subunits. The mechanism of T6SS sheath contracti […]
E2F1 is the main pro-apoptotic effector of the pRB-regulated tumor suppressor pathway by promoting the transcription of various pro-apoptotic proteins. We report here that E2F1 partly localizes to mitochondria, where it favors mitochondrial outer membrane permeabilization. E2F1 interacts with BCL-xL independently from its BH3 binding interface and induces a […]
Vuillier, C., Lohard, S., Fetiveau, A., Allegre, J., Kayaci, C., King, L. E., Braun, F., Barille-Nion, S., Gautier, F., Dubrez, L., Gilmore, A. P., Juin, P. P., Maillet, L.
The race to become crowned as the World’s Most Unloved Species was hotly contested, once again, this year with 19 nominated species in the running. After 12 days of fierce competition, impassioned pitches and over 4,500 votes, the top 10 was announced on Valentine’s Day. But slithering into first place… it’s the Galapagos racer! Often […]
Species name: thorny skate Nominated by: Shark Advocates International IUCN Red List classification: Vulnerable What is so special about your species? Thorny skates have amazing features, support substantial fisheries, and face serious threats. Yet, they get so little love. This fierce-looking, bottom-dwelling species has a dozen or more large thorns running […]
Species name: goliath frog Nominated by: Synchronicity Earth IUCN Red List classification: Endangered What is so special about your species? The goliath frog is the world’s largest frog. It is known only from south-western Cameroon from the region of Nkongsamba, and south to Monte Alen in mainland Equatorial Guinea. It is generally found at low to […]
Species name: shortfin mako Nominated by: The Shark Trust IUCN Red List classification: Vulnerable; Critically Endangered – Mediterranean What is so special about your species? Sleek and fast, the shortfin mako is capable of reaching speeds of over 30mph, making it the fastest shark in the world. On top of this, it has the power to […]