Aggregation of α-synuclein is a hallmark of Parkinson's disease and dementia with Lewy bodies. We here investigate the relationship between cytosolic Ca2+ and α-synuclein aggregation. Analyses of cell lines and primary culture models of α-synuclein cytopathology reveal an early phase with reduced cytosolic Ca2+ levels followed by a later Ca2+ increase. […]
Betzer, C., Lassen, L. B., Olsen, A., Kofoed, R. H., Reimer, L., Gregersen, E., Zheng, J., Cali, T., Gai, W.-P., Chen, T., Moeller, A., Brini, M., Fu, Y., Halliday, G., Brudek, T., Aznar, S., Pakkenberg, B., Andersen, J. P., Jensen, P. H.
Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological decline. Our data reveal a novel interplay between senescence and the stress response that affects both the p […]
Omer, A., Patel, D., Lian, X. J., Sadek, J., Di Marco, S., Pause, A., Gorospe, M., Gallouzi, I. E.
Cenp-F is a multifaceted protein implicated in cancer and developmental pathologies. The Cenp-F C-terminal region contains overlapping binding sites for numerous proteins that contribute to its functions throughout the cell cycle. Here, we focus on the nuclear pore protein Nup133 that interacts with Cenp-F both at nuclear pores in prophase and at kinetochore […]
Berto, A., Yu, J., Morchoisne-Bolhy, S., Bertipaglia, C., Vallee, R., Dumont, J., Ochsenbein, F., Guerois, R., Doye, V.
When Drosophila melanogaster feeds on Pseudomonas aeruginosa, some bacteria cross the intestinal barrier and eventually proliferate in the hemocoel. This process is limited by hemocytes through phagocytosis. P. aeruginosa requires the quorum-sensing regulator RhlR to elude the cellular immune response of the fly. RhlI synthesizes the autoinducer signal that […]
Haller, S., Franchet, A., Hakkim, A., Chen, J., Drenkard, E., Yu, S., Schirmeier, S., Li, Z., Martins, N., Ausubel, F. M., Liegeois, S., Ferrandon, D.
Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best-understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusception, or vascular splitting, whose molecular regulation is essentially unknown. Here, we identify ephrinB2/EphB4 si […]
Groppa, E., Brkic, S., Uccelli, A., Wirth, G., Korpisalo-Pirinen, P., Filippova, M., Dasen, B., Sacchi, V., Muraro, M. G., Trani, M., Reginato, S., Gianni-Barrera, R., Ylä-Herttuala, S., Banfi, A.
Peroxisomes account for ~35% of total H2O2 generation in mammalian tissues. Peroxisomal ACOX1 (acyl-CoA oxidase 1) is the first and rate-limiting enzyme in fatty acid β-oxidation and a major producer of H2O2. ACOX1 dysfunction is linked to peroxisomal disorders and hepatocarcinogenesis. Here, we show that the deacetylase sirtuin 5 (SIRT5) is present in perox […]
Mitochondria are fundamental for cellular metabolism as they are both a source and a target of nutrient intermediates originating from converging metabolic pathways, and their role in the regulation of systemic metabolism is increasingly recognized. Thus, maintenance of mitochondrial homeostasis is indispensable for a functional energy metabolism of the whol […]
Becker, C., Kukat, A., Szczepanowska, K., Hermans, S., Senft, K., Brandscheid, C. P., Maiti, P., Trifunovic, A.
In most mammalian cells, the primary cilium is a microtubule-enriched protrusion of the plasma membrane and acts as a key coordinator of signaling pathways during development and tissue homeostasis. The primary cilium is generated from the basal body, and cancerous inhibitor of protein phosphatase 2A (CIP2A), the overexpression of which stabilizes c-MYC to s […]
Jeong, A. L., Ka, H. I., Han, S., Lee, S., Lee, E.-W., Soh, S. J., Joo, H. J., Sumiyasuren, B., Park, J. Y., Lim, J.-S., Park, J. H., Lee, M. S., Yang, Y.
Scar formation after brain injury is still poorly understood. To further elucidate such processes, here, we examine the interplay between astrocyte proliferation taking place predominantly at the vascular interface and monocyte invasion. Using genetic mouse models that decrease or increase reactive astrocyte proliferation, we demonstrate inverse effects on m […]
Frik, J., Merl-Pham, J., Plesnila, N., Mattugini, N., Kjell, J., Kraska, J., Gomez, R. M., Hauck, S. M., Sirko, S., Götz, M.
It’s our birthday! Arkive is 15 years old! We’re thrilled to be able to celebrate and share the incredible diversity of life on Earth. However our planet is currently under a crisis, our planet’s ecosystems are under threat like never before, and the world is watching as more and more species fall victim to habitat […]
To celebrate the launch of the inaugural Wildscreen Photo Story Panda Award at this year’s Wildscreen Festival, Arkive is getting to know the award’s amazing jury, who are themselves international photography professionals. Here we meet Jasper Doest. Tell us a little bit about yourself? I was born and raised close to Rotterdam in The Netherlands and that’s w […]
To celebrate the launch of the inaugural Wildscreen Photo Story Panda Award at this year’s Wildscreen Festival, Arkive is getting to know the award’s amazing jury, who are themselves international photography professionals. Here we meet Peter Cairns. Tell us a little bit about yourself? I spent my childhood in the English Midlands, but I’ve been […] […]
For the first time in its 36 year history, the 2018 Wildscreen Panda Awards, widely regarded as the most prestigious accolade in the wildlife film and TV genre, will recognise the craft of wildlife photography, with the introduction of the Wildscreen Photo Story Panda Award. The Panda Awards ceremony is the flagship event of the […]