One of Earth's rarest fish, the Devil's Hole pupfish, is often cited as an unusual example of a small but long-lasting population of animals. But these fish may not have been isolated for as long as once thought.Less than 100 adult pupfish (Cyprinodon
A group of small molecules can spur the growth of stem cells from umbilical cord blood. These could one day be used as transplants to treat, for example, certain blood cancers.Guy Sauvageau at the University of Montreal in Canada and his colleagues screened a
Guidance for mitigation action should come from the insights that global mean temperatures respond to cumulative carbon emissions and that there are risks beyond warming alone. Momentum for the negotiations requires a sense of opportunity.
The emerging scientific focus on cumulative carbon emissions may make climate negotiations harder. But, it serves to clarify the scale and scope of climate mitigation needed to meet potential temperature targets.
Jupiter's icy moon Europa is criss-crossed by extensional features. A tectonic reconstruction suggests that Europa's extension is balanced by subduction — if so, Earth may not be the only planetary body with a plate tectonic system.
More than 30% of all human cancers contain activating mutations of the small G-protein RAS. As a result of this, RAS has been intensely studied and many efforts have been made to identify pathways that sustain RAS-driven transformation . Recent studies have indicated that the transcription factor GATA2 is one of these partners in crime, but a mechanistic […]
Differentiating left and right hand sides during embryogenesis represents a major event in body patterning. Left–Right (L/R) asymmetry in bilateria is essential for handed positioning, morphogenesis and ultimately the function of organs (including the brain), with defective L/R asymmetry leading to severe pathologies in human. How and when symmetry is initia […]
Coutelis, J.-B., Gonzalez-Morales, N., Geminard, C., Noselli, S.
Disease mutations provide unique opportunities to decipher protein and cell function. Mutations in the master regulator of hematopoiesis GATA-2 underlie an immunodeficiency associated with myelodysplastic syndrome and leukemia. We discovered that a GATA-2 disease mutant (T354M) defective in chromatin binding was hyperphosphorylated by p38 mitogen-activated p […]
Katsumura, K. R., Yang, C., Boyer, M. E., Li, L., Bresnick, E. H.
Sister chromatid cohesion, which depends on cohesin, is essential for the faithful segregation of replicated chromosomes. Here, we report that splicing complex Prp19 is essential for cohesion in both G2 and mitosis, and consequently for the proper progression of the cell through mitosis. Inactivation of splicing factors SF3a120 and U2AF65 induces similar coh […]
Watrin, E., Demidova, M., Watrin, T., Hu, Z., Prigent, C.
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency, leading to globally enhanced intron retention. Defective si […]
Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J., Hakobyan, A., Mistrik, M., Choudhary, C., Rohde, M., Bekker-Jensen, S., Mailand, N.
The tactile sensors in our fingers have variable sensitivity across the skin. Does this variability harm or help the CNS in touch perception? Work now shows that this variability may provide the CNS with more information about micropositioning and stimulus orientation.
How do enhancers facilitate transcription of plasticity-related genes in response to synaptic stimulation? A study implicates a specific histone modification and suggests that FOS regulates enhancer function.
Long axonal projections seem to be metabolically coupled to ensheathing glial cells. Targeting LKB1, a regulator of energy homeostasis, specifically in Schwann cells causes a loss of predominantly small unmyelinated fibers.
At Arkive, we are ever grateful for the support we receive from individuals whether they be photographers and filmmakers who donate their work to make Arkive possible, conservationists & researchers who passionately pursue the science and stories behind the world’s most threatened species, or teachers who bring the WILD into their classroom everyday with […]
Wildscreen Photography Festival is THE must-attend event in the wildlife photography calendar. This annual gathering of the world’s very best wildlife and environmental photographers gives you the chance to immerse yourself in the sheer wonder of the natural world. You can discover the stories behind some of the most iconic wildlife images of recent times as […]
This October, Bristol will be hosting a comedy night with a difference! If you’re in the UK, join us for a night of laughter and hilarity at Colston Hall, hosted by Simon Watt (Inside Nature’s Giants, the Infinite Monkey Cage) as we seek to delve deep into some of the weirdest creatures on this earth. […]
What is SINNG? The Student Invasive Non-Native Group or SINNG is a Local Action Group based at Cornwall College, Newquay. Launched in 2010, our goal is to increase awareness and reduce the impacts caused by Invasive Non-Native Species (INNS) on native wildlife. We do this through practical fieldwork such as pond clearings, Himalayan Balsam removal […]