Birds that have the longest evolutionary history are also the most threatened by agriculture.Luke Frishkoff at Stanford University in California, Daniel Karp at the University of California, Berkeley, and their team studied 12 years of bird survey data, covering nearly 500 species from three
The region in Africa at risk of an outbreak of the Ebola virus is larger than previously thought.Simon Hay at the University of Oxford, UK, and his team mapped data from 23 Ebola outbreaks in humans, including the current one, and 51 reports of
At Nature Publishing Group we offer a transfer system that allows authors to move papers between our journals at the click of a button if their first-choice journal declined. We encourage authors to use that service.
Particles of smoke from natural and human-made fires absorb sunlight and contribute to global warming. Laboratory experiments suggest that smoke is often more absorbing than current numerical models of global climate assume.
Multicellular animals probably evolved at the seafloor after a rise in oceanic oxygen levels. Biogeochemical model simulations suggest that as these animals started to rework the seafloor, they triggered a negative feedback that reduced global oxygen.
In 2004, a phase transition was discovered in the most abundant lower-mantle mineral. A decade of focused experiments, computations and seismic imaging stimulated by this discovery has revealed previously unknown complexities in Earth's deep mantle.
More than 30% of all human cancers contain activating mutations of the small G-protein RAS. As a result of this, RAS has been intensely studied and many efforts have been made to identify pathways that sustain RAS-driven transformation . Recent studies have indicated that the transcription factor GATA2 is one of these partners in crime, but a mechanistic […]
Differentiating left and right hand sides during embryogenesis represents a major event in body patterning. Left–Right (L/R) asymmetry in bilateria is essential for handed positioning, morphogenesis and ultimately the function of organs (including the brain), with defective L/R asymmetry leading to severe pathologies in human. How and when symmetry is initia […]
Coutelis, J.-B., Gonzalez-Morales, N., Geminard, C., Noselli, S.
Disease mutations provide unique opportunities to decipher protein and cell function. Mutations in the master regulator of hematopoiesis GATA-2 underlie an immunodeficiency associated with myelodysplastic syndrome and leukemia. We discovered that a GATA-2 disease mutant (T354M) defective in chromatin binding was hyperphosphorylated by p38 mitogen-activated p […]
Katsumura, K. R., Yang, C., Boyer, M. E., Li, L., Bresnick, E. H.
Sister chromatid cohesion, which depends on cohesin, is essential for the faithful segregation of replicated chromosomes. Here, we report that splicing complex Prp19 is essential for cohesion in both G2 and mitosis, and consequently for the proper progression of the cell through mitosis. Inactivation of splicing factors SF3a120 and U2AF65 induces similar coh […]
Watrin, E., Demidova, M., Watrin, T., Hu, Z., Prigent, C.
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency, leading to globally enhanced intron retention. Defective si […]
Oka, Y., Varmark, H., Vitting-Seerup, K., Beli, P., Waage, J., Hakobyan, A., Mistrik, M., Choudhary, C., Rohde, M., Bekker-Jensen, S., Mailand, N.
Two independent epigenome-wide association studies of Alzheimer's disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer's disease. These studies also suggest that epigenetic changes contribute more to Alzheimer's disease than expected.
Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.
In this issue, Shenhav et al. critically evaluate the idea that neural correlates of value actually represent value. They describe how, in many situations, value correlates can reflect other cognitive factors, such as decisional difficulty.
Wildscreen Photography Festival is THE must-attend event in the wildlife photography calendar. This annual gathering of the world’s very best wildlife and environmental photographers gives you the chance to immerse yourself in the sheer wonder of the natural world. You can discover the stories behind some of the most iconic wildlife images of recent times as […]
This October, Bristol will be hosting a comedy night with a difference! If you’re in the UK, join us for a night of laughter and hilarity at Colston Hall, hosted by Simon Watt (Inside Nature’s Giants, the Infinite Monkey Cage) as we seek to delve deep into some of the weirdest creatures on this earth. […]
What is SINNG? The Student Invasive Non-Native Group or SINNG is a Local Action Group based at Cornwall College, Newquay. Launched in 2010, our goal is to increase awareness and reduce the impacts caused by Invasive Non-Native Species (INNS) on native wildlife. We do this through practical fieldwork such as pond clearings, Himalayan Balsam removal […]
Denise Spaan is the Field Station Coordinator and Conservation Education Manager for The Little Fireface Project which was set up to help protect the slow loris in Indonesia. We caught up with Denise to ask her more about this fascinating species and the important work being done to conserve it. How did you get into […]