European law has allowed citizens to force a debate on human embryonic stem cells less than a year after the previous one. This fruitless democratic exercise has left scientists spinning in uncertainty.
Dead trees at the bottom of the ocean host a diverse range of bacteria, fungi and molluscs (pictured; a cent is included for scale).Craig McClain of the National Evolutionary Synthesis Center in Durham, North Carolina, and James Barry of the Monterey Bay Aquarium Research
A device that controls light so that it travels in just one direction could be used in high-speed computers that carry signals using light, rather than electric charges.A team led by Lan Yang and Şahin Kaya Özdemir at Washington University in St. Louis created
Infant formula and breastfeeding are environmental factors that influence the incidence of Type 1 Diabetes (T1D) as well as the acidity of newborn diets. To determine if altering the intestinal microbiome is one mechanism through which an acidic liquid plays a role in T1D, we placed non-obese diabetic (NOD)/ShiLtJt mice on neutral (N) or acidified H2O and mo […]
Wolf, K. J., Daft, J. G., Tanner, S. M., Hartmann, R., Khafipour, E., Lorenz, R. G.
The microenvironments of organs with blood flow affect the metabolic profiles of cancer cells, which are influenced by mitochondrial functions. However, histopathological analyses of these aspects have been hampered by technical artifacts of conventional fixation and dehydration, including ischemia/anoxia. The purpose of this study was to combine the in vivo […]
Lei, T., Huang, Z., Ohno, N., Wu, B., Sakoh, T., Saitoh, Y., Saiki, I., Ohno, S.
High-speed fluorescence-activated cell sorting is relevant for a plethora of applications, such as PCR-based techniques, microarrays, cloning, and propagation of selected cell populations. We suggest a simple cell-sorting technique to eliminate early and late apoptotic and necrotic cells, with good signal-to-noise ratio and a high-purity yield. The mitochond […]
Barteneva, N. S., Ponomarev, E. D., Tsytsykova, A., Armant, M., Vorobjev, I. A.
Various types of endogenous stem cells (SCs) participate in wound healing in the skin at different anatomical locations. SCs need to be identified through multiple markers, and this is usually performed using flow cytometry. However, immunohistological identification of endogenous stem cells in the skin at different anatomical locations by co-staining multip […]
A finding now suggests that the brain's response to heartbeats is influential in guiding reported visual experience, such that the ability to accurately report the presence or absence of a visual target is influenced by the brain's heartbeat-evoked activity.
CNS white matter injury may cause sustained demyelination despite the persistence of oligodendrocyte progenitor cells (OPCs). A study suggests that dysregulated Wnt signaling disrupts self-renewal to yield OPC maturation arrest.
A study now shows that granule cells deep in the olfactory bulb exhibit wildly different response dynamics depending on behavioral state, suggesting they could configure network changes across behavioral states.
The internal dynamics of recurrent cortical circuits is crucial to brain function. We now learn that simply increasing the strengths of recurrent connections shifts neural dynamics to a potentially powerful computational regime.
Several methods have been reported for the growth of monolayer graphene into areas large enough for integration into silicon electronics. However, the electronic properties of the graphene – [Read More]
The faithful segregation of chromosomes into daughter cells is essential for cellular and organismal viability. Errors in this process cause aneuploidy, a hallmark of cancer and several congenital diseases. For proper separation, chromosomes attach to microtubules of the mitotic spindle via their kinetochores, large protein structures assembled on centromeri […]
During vertebrate development, a wide variety of cell types and tissues emerge from a single fertilized oocyte. One of these tissues, the central nervous system, contains many types of neurons and glial cells that were born during the period of embryonic and post-natal neuro- and gliogenesis. As to neurogenesis, neural progenitors initially divide symmetrica […]